Marylee Z. Southard

Education

• BS, Chemical Engineering, University of Kansas
• MS, Chemical Engineering, University of Kansas
• PhD, Chemical Engineering, University of Kansas

Research Interests

Marylee Southard's research interests are in the design and analysis of chemical transport processes, specifically those in which bioactive agents are released. This research area is multidisciplinary in nature because workers in other disciplines usually define the chemical of interest and the problems associated with its movement. Her usual role (and interest) in a collaborative venture is to analyze mathematically the desired and/or existing mode of release and to design a novel means of achieving or altering that mode. Numerical methods and software are used as tools to simulate chemical transport in diverse types of tissue, across membranes and other barriers. Cellular growth, metabolism and carrier-mediated uptake are also simulated mathematically to mimic the in vivo environment. Simulation of behavior in a given environment allows collaborators to optimize of the number of experiments required to design an optimal chemical formulation or diagnostic device. Dr. Southard's ultimate goal in this work is to enhance understanding of biological processes as related to drug therapies, disease states, and pathological conditions. Her funding has come from federal, state and industrial sources.

Peer Reviewed Publications

• Chakrabarti, S. and Southard, M.Z. "Control of Poorly Soluble Drug Dissolution in Conditions Simulating the Gastrointestinal Tract Flow. I: Effect of Tablet Geometry in Buffered Medium", J. Pharm. Sci. 1996, 85, 313-319.
• Patent: "Totally Degradable Starch/Polymer Matrices for Controlled Release", U.S. patent no. 5,565,407; issued October, 1996.
• Chakrabarti, S. and Southard, M.Z. "Control of Poorly Soluble Drug Dissolution in Conditions Simulating the Gastrointestinal Tract Flow. II: Co-compression of Drugs with Buffers", J. Pharm. Sci., 1997, 86, 465-469.
• Stenken, J.A., Stavle, L., Southard, M.Z. and Lunte, C.E., "Factors that Influece Microdialysis Extraction Efficiency. II. Teoretical and Experimental Evaluations", J. Pharm. Sci., 1997, 86, 958-966.
• Rao, V.M., Lin, M., Larive, C.K. and Southard, M.Z. "A Mechanistic Study of Griseofulvin Dissolution into Surfactant Solutions under Laminar Flow Conditions", J. Pharm. Sci., 1997, 86, 1132-1138.
• Stenken, J.A., Stavle, L., Lunte, C.E. and Southard, M.Z.., "Monitoring in stu Liver Metabolism in Rats using Microdilysis. Comparison of Microdialysis Mass-Transport Model to Experimental Metabolite Generation Data", J. Pharm. Sci., 1998, 87, 311-320.